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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1948
Report Date:
1948

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Concentrated and 10% water solution was applied to clipped rabbit trunk under Vinylite sheeting.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Concentration 76% ethylenediamine

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
0.5 - 0063 - 0.795 - 1 mg/kg of concentrated sample
10% solutions 1.20 - 1.52 mg/kg
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
560 mg/kg bw
Sex:
male
Dose descriptor:
approximate LD50
Effect level:
ca. 1 520 mg/kg bw
Remarks on result:
other: In 10% diluted solution

Any other information on results incl. tables

Necrosis of the skin, congestion of the lungs and damage to the abdominal organs was noted on autopsy.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 in an acute dermal toxicity test on rabbit was 560 mg/kg.
Executive summary:

Rabbits were exposed to concentrated ethylene diamine (76%) and a 10% dilution in water under occlusive coverage for 24 h. With the concentrated substance, severe skin damage occurred. Congestion of the lungs and damage to the abdominal organs was noted on autopsy. LD50 was 560 mg/kg bw. For the diluted samples LD50 was approximately 1520 mg/kg bw.