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EC number: 203-468-6
CAS number: 107-15-3
Following a single or repeated oral administration (up to 18 month) to Fischer 344 rats there were no age-, sex-, and/or chronic dosing-related differences in absorption rate constant or terminal half-life for plasma elimination. However, significant age-related changes in area under the curve (AUC) were evident: The older rats had approximately two- to threefold higher AUC values than the younger ones (Table 1); the volume of distribution in the older rats was between a fourth and a half of the value in the younger rat (Table 2). There was much more EDA present in the systemic circulation in the older rats than the younger rats. Similarly, the older rats had much smaller volumes of distribution on the basis of liters/kg body weight. This indicates that EDA is distributed through a proportionally smaller circulatory and tissue volume in the older rats.
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