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EC number: 203-468-6
CAS number: 107-15-3
Skin and eye irritation tests with rabbit shows that ethylene diamine is corrosive to skin and eye, there is no study available for determiantion of respiratory irritation.
Mean erythema score after 24, 48
and 72 h (animal1/2)
Already a 1 min exposure with
ethylenediamine caused necrosis to the exposed skin.
The original BASF grading was
converted into the numerical grading according the OECD Draize system.
In a skin irritation/corrosion test, Vienna White rabbits were exposed
to ethylene diamine.Two animals were treated for 1, 5 and 15 min using
occlusive conditions. An application site of 2.5x2.5 cm was covered with
the liquid test substance. After the application time the skin was
washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were
observed for 14 days and skin changes were recorded daily.
-/-: The original readings at 48 h
#/# : A thick purlulence layer
made an evaluation impossible.
1 h post application heavy opacity
and distinct irritation of the mucous membrane were observed and bloody
eye discharge occured. Grey discoloration of nictitating and mucous
membrane. The severe corneal opacity is regarded to be irreversible.
Two Vienna White rabbits were exposed to 50 µl ethylene amine in
one eye. Observations were made after 10 min, 1 and 3 h on the
day of treatment and up to 8 days afterwards. The eyes were not washed
out after 24 hours as specified in OECD Guideline 405. Irreverible
damage to eyes was reported.
Based on the available data for skin corrosion, ethylene diamine is
shown to be corrosive to skin. A 1min exposure showed necrosis at
observation after 24h.
Irreversible damage to eye after exposure was shown in a study.
Observations were made after 10 min, 1 and 3 h on the day of treatment
and up to 8 days afterwards. The eyes were not washed out after 24 hours
as specified in OECD Guideline 405.
Ethylene diamine is classified as corrosive cat 1B to skin and corrosive
to eye according to harmonised EU classification, and the available data
supports this classification.
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