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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: not guideline compliant and irrelevant administration route

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Intraperitoneal injection
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-2-methylpropiophenone
EC Number:
231-272-0
EC Name:
2-hydroxy-2-methylpropiophenone
Cas Number:
7473-98-5
Molecular formula:
C10H12O2
IUPAC Name:
2-hydroxy-2-methyl-1-phenylpropan-1-one

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
peanut oil
Doses:
Five doses between 4000 and 10000 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
824 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated

Applicant's summary and conclusion

Conclusions:
After acute intraperitoneal injection of Darocur 1173 to Wistar rats, a LD50 of 824 mg/kg was calculated.