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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only abstract available.

Data source

Reference
Reference Type:
publication
Title:
Trichloroacetic acid accumulates in amniotic fluid after tri- and tetrachloroethylene inhalation by mice
Author:
Ghantous H, Danielsson BRG, Dencker L, Gotczak J and Vesterberg O
Year:
1986
Bibliographic source:
Acta Pharmacol Toxicol (Copenh). Feb; 58(2):105–114

Materials and methods

Principles of method if other than guideline:
Trichloroacetic acid was infused i.v. in the maternal plasma. The concentration in the amniotic fluid was studied.
GLP compliance:
not specified
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetic acid
EC Number:
200-927-2
EC Name:
Trichloroacetic acid
Cas Number:
76-03-9
Molecular formula:
C2HCl3O2
IUPAC Name:
trichloroacetic acid

Results and discussion

Applicant's summary and conclusion

Conclusions:
The results suggest that trichloroacetic acid may be transported to the fetus partly para-placentally, with the possibility of fetal swallowing or absorption through the skin.
Executive summary:

Trichloroacetic acid infused i.v. in the maternal plasma accumulated in amniotic fluid but less pronounced than after trichloroethylene and tetrachloroethylene inhalation, indicating that some metabolism of trichloroethylene and tetrachloroethylene to trichloroacetic acid may occur in the feto-placental unit. The results suggest that trichloroacetic acid may be transported to the fetus partly para-placentally, with the possibility of fetal swallowing or absorption through the skin.