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EC number: 200-927-2
CAS number: 76-03-9
Repeated dose toxicity: oral. Key studies: Read-across: experimental results with the substance sodium trichloroacetate.
Repeated dose toxicity: oral. Key studies: Read-across: experimental
results with the substance sodium trichloroacetate.
Free trichloroacetic acid is a strong organic acid, which forms
water-soluble salts with bases. In any medium at or near neutral pH the
predominant form present is the trichloroacetate anion. The salts are
therefore expected to be toxicologically equivalet to the free acid,
except for the acute corrosive properties, which are at least partly
determined by the very low pH of strong solutions of the acid.
In a 90-day study with dogs, from 2000 ppm upwards effects were observed
in mortality, body weights, haematology, urinalysis, gross pathology and
histopathology. Therefore, the NOEL was determined to be 500 ppm
(approximately 30 mg/kg bw/day).
In a 4-month study with rats, the NOEL was determined to be 4000 ppm
(approximately 365 mg/kg bw/day), based on body weight reduction
observed at 10000 ppm.
In a 2-year study in rats, the NOEL was determined as 1600 ppm
(approximately 80 mg/kg bw/day), based on a significantly body weight
reduction observed at 10000 ppm.
Based on the molecular weights, the NOELs for trichloroacetic acid would
be as follows:
- 90 -day study with dogs: 26 mg/kg bw/day.
- 4 -month study with rats: 322 mg/kg bw/day.
- 2 -year study in rats: 70.5 mg/kg bw/day
Based on the results obtained in the different repeated dose toxicity
studies, the substance is not classified for specific target organ
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