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EC number: 200-927-2
CAS number: 76-03-9
Sixteen men with actinic damage including actinic keratoses were treated
with a 40% trichloroacetic acid chemical peel. Half were pretreated for
6 weeks with topical tretinoin; they also used tretinoin after the peel.
Photographs were obtained at baseline and at 6 weeks and 6 months after
treatment. Changes in specific features were rated by a panel of three
examiners. Some improvement was noted in all patients. More rapid and
even frosting was observed in the patients pretreated with tretinoin.
Solar lentigines, actinic keratoses, and skin texture were the features
of photoaging most affected; wrinkles were least affected. No
statistically significant difference was found between patients treated
with trichloroacetic acid and tretinoin (before and after peel) and
those with trichloroacetic acid alone. A medium-depth chemical peel with
40% trichloroacetic acid alone produced moderate improvement in some
manifestations of actinic damage but had little effect on wrinkles.
Treatment with tretinoin before and after trichloroacetic acid did not
significantly enhance the efficacy of the peel.
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