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Registration Dossier
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EC number: 200-927-2 | CAS number: 76-03-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication peer reviewed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Type of study / information:
- In vitro hepatotoxicity (cytotoxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trichloroacetic acid
- EC Number:
- 200-927-2
- EC Name:
- Trichloroacetic acid
- Cas Number:
- 76-03-9
- Molecular formula:
- C2HCl3O2
- IUPAC Name:
- trichloroacetic acid
- Details on test material:
- - Name of test material (as cited in study report): trichloroacetic acid (TCA)
- Analytical purity: 99%
Constituent 1
Results and discussion
Any other information on results incl. tables
Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular glutathione (GSH) status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.
Applicant's summary and conclusion
- Conclusions:
- It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.
- Executive summary:
In the present study the in vitro cytotoxicity of trichloroacetic acid was determined in hepatocyte suspensions prepared from naive and clofibric acid-pretreated male Sprague-Dawley rats and B6C3F1 mice. Trichloroacetic acid produced no evidence of cytotoxicity in hepatocytes from naive or clofibric acid-pretreated animals of either species at concentrations up to 5.0 mM. Trichloroacetic acid did not alter cellular GSH status in hepatocytes isolated from either Sprague-Dawley rats or B6C3F1 mice. It was concluded from these in vitro observations that trichloroacetic acid is not highly cytotoxic to hepatocytes.
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