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EC number: 200-927-2
CAS number: 76-03-9
Toxicity to microorganisms: Weight of evidence: Experimental results obtained with the substance trichloroacetic acid and read-across from the results obtained with sodium trichloroacetate.
Toxicity to microorganisms: Weight of evidence: Experimental results
obtained with the substance trichloroacetic acid and read-across from
the results obtained with sodium trichloroacetate.
In an activated sludge respiration inhibition test, conducted with
industrial activated sludge exposed to the substance trichloroacetic
acid, the 24 -h EC20 was higher than 750 mg/l.
The luminiscent bacteria toxicity (LBT) test was performed on the marine
phosphorescent bacterium Photobacterium phosphoreum. This test was
conducted using the Microtox Toxicity Analyzer System. The EC50 for
trichloroacetic acid in the LBT test was 35 mg/l. Single species test
with Photobacterium phosphoreum (Vibrio fischeri) should be considered
of low relevance for STPs (Sewage Treatment Plants).
Free trichloroacetic acid is a strong organic acid, which forms
water-soluble salts with bases. In any medium at or near neutral pH the
predominant form present is the trichloroacetate anion. The salts are
therefore expected to be toxicologically equivalet to the free acid,
except for the acute corrosive properties, which are at least partly
determined by the very low pH of strong solutions of the acid. Using
analogous methods of the cell multiplication inhibition test, the
toxicity threshold (TT) of sodium trichloroacetate was determined for
model organisms. The toxicity threshold was greater than 1000 mg/l for
the bacteria Pseudomonas putida and 800 mg/l for the protozoan species
The assimilation-depletion test (A-D test) was performed. The oxygen
consumption of a natural bacterial population (depletion test) serves as
measurement criteria. The 24 -h EC10 for sodium trichloroacetate for a
mixture culture of heterotrophic bacteria was greater than 1000 mg/l.
A method of testing the toxicity of sodium trichloroacetate to bacterial
organisms was performed at concentrations ranging from 10 to 1000 mg/l.
After incubation of 24 hours at 30 ºC, the measurement of bacterial
toxicity was carried out by determining the minimum inhibitory
concentration (MIC) in mg/l of the test substance. The MIC was 1000 mg/l
for the tested species Aeromonas hydrophila and Bacillus subtilis.
Based on the results obtained with the substance sodium trichloroacetate
and applying the read-across approach taking into account the molecular
weights of the substances, it is concluded that for the substance
trichloroacetic acid, the toxicity threshold for the species Pseudomonas
putida and the 24 -h EC10 for a mixture culture of heterotrophic
bacteria would be greater than 880 mg/l. The MIC for the species
Aeromonas hydrophila and Bacillus subtilis would be 880 mg/l.
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