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EC number: 211-185-4
CAS number: 632-79-1
The NOEL in the TBPA pilot prenatal
developmental study in the rat was 3000 mg/kg. The NOEL for TCPA in the
rat prenatal developmental study was 1000 mg/kg. The NOEL for
reproductive organs in rats and mice of TCPA after 13 weeks
administration was 1500 mg/kg.
TBPA: pilot prenatal developmental in the rat.TCPA (tetrachlorophthalic anhydride): rat prenatal developmental, rat and mouse 13 week studies with additional investigation of sperm morphology and vaginal cytology.
The combination of data on reproductive
organs from subchronic studies in two species and prenatal developmental
studies indicate TBPA and TCPA do not affect reproduciton.
The lack of effects on the reproductive
organs and in prenatal developmental studies in more than one species
for TBPA or TCPA indicates the substance is not a reproductive toxicant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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