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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Reported by the U.S. National Toxicology Program and published in the peer reviewed literature.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1993
Reference Type:
publication
Title:
Chemical mutagenesis testing in Drosophilia. III. Results of 48 coded compouonds tested for the National Toxicology Program.
Author:
Valencia et al.
Year:
1985
Bibliographic source:
Environ. Mutagen 7, 325-348.

Materials and methods

Principles of method if other than guideline:
See Valencia et al. (1985) Environ. Mutagen 7, 325-348.
GLP compliance:
yes
Type of assay:
somatic mutation and recombination test in Drosophila

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
see rat and mouse 13 week studies

Test animals

Species:
Drosophila melanogaster
Strain:
other: Canton-S wild-type
Sex:
male

Administration / exposure

Route of administration:
other: abdominal injection
Vehicle:
saline or peanut oil
Duration of treatment / exposure:
single injection
Frequency of treatment:
once
Doses / concentrations
Remarks:
Doses / Concentrations:
o, 500 ppm
Basis:
nominal conc.
No. of animals per sex per dose:
see Valencia et al. 1985
Control animals:
yes, concurrent vehicle

Examinations

Tissues and cell types examined:
see Valencia et al. 1985

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly.
Executive summary:

Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly.