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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Two 96 hr tests in fish, and estimated values.

Key value for chemical safety assessment

LC50 for freshwater fish:
10 mg/L
LC50 for marine water fish:
20.471 mg/L

Additional information

Two short-term studies are currently available on trout and bluegill sunfish. Range concentration tested were between 0 -10 mg/L. LC50 (96h) for both tests were > 10 mg/L, the highest dose tested.

The ECOSAR-estimated 96 -hr LC50 in freshwater fish for the hydrolysis product TBPA-acid* is 17.983 mg/L, which is higher than the ECOSAR-estimated water solubility (0.104 mg/L) of the hydrolysis product. The ECOSAR-estimated LC50 of TBPA-acid in saltwater fish is 20.471 mg/L, which is higher than the estimated water solubiity. Based on this, neither TBPA nor TBPA-acid are expected to be toxic to fish.

*ECOSAR class for TBPA-acid is Neutral Organics-acid (ECOSAR V1.00)

Interestingly, when running ECOSAR for TBPA-anhydride* with the measured water solubility (see section 4.8), the LC50 (96 hrs) to fish is 372.167 mg/L in freshwater meaning that the substance should not be toxic when running flow through experiment.Same conclusion when running the tool for marine environment where a value of 518,201 mg/L was calculated.

*ECOSAR class for TBPA-anhydride is Neutral Organics (ECOSAR V1.00)