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EC number: 211-185-4
CAS number: 632-79-1
TBPA: 28 D rabbit dermal; 21 D rat inhalationTCPA (tetrachlorophthalic anhydride): 13 Wk rat gavage, 13 WK mouse gavage
TBPA has been tested in a 28 day rabbit
dermal and 21 day rat inhalation studies. In the inhalation study, no
adverse effects were noted at 2 mg/L. In the dermal study, all rabbits
at the top dose of 5000 mg/kg died or were sacrificed prior to the
study's end. The NOAEL for systemic toxicity in that study was the next
highest dose, 500 mg/kg. Hisptopathlogy was not performed at the 5000
mg/kg dose, and limited clinical pathology indicated an increase in BUN, and
albumin and glucose in the urine. These changes are indicative of an effect
on the kidney. TBPA's structural analog, tetrachlorophthalic anhydride
or TCPA, has been tested in the rat and mouse in 13 week studies with
administration via gavage. Mice were not affected by doses up to 1500
mg/kg. Rats, however, were affected and the LOAEL was 94 mg/kg. Although
no clinical pathology changes clearly associated with treatment were
observed, rats exhibitied dose-dependent increases in kidney weights and
in the incidence and severity of renal tuble necrosis and/or dilation. Thus,
TCPA and TBPA appear to be renal toxicants in the rat and rabbit, respectively.
Mice, however, appear resistent.
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