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EC number: 211-185-4
CAS number: 632-79-1
1Temperature was continuously monitored in a container of water located adjacent to the study with an Amegaview Scientific centralized monitoring system.
Mean Measured Test Concentration (mg/L)
1Day 0 samples were collected from the individual batches of test solutions prepared for each treatment and control group at test initiation.
2Day 3 samples were from pooled samples of test solution collected from the three replicates per treatment and six replicates in the control group at test termination.
of R. subcapitata Growth After 72 Hours of Exposure to
72 Hours of Exposure1
Mean Cell Density (cell/mL)3*
Mean Growth Rate (hours-1)*
Mean Yield (cells/mL)3*
1Calculations were performed using SAS Version 9.4. Manual calculations may differ slightly.
2Inhibition was calculated relative to the mean negative control response.
3Yield was calculated as the final cell density minus the nominal initial cell density (10,000 cells/mL).
*None of the treatment group means were significantly different from the negative control mean (Dunnett’s test, P>0.05)
The objective of the study
was to determine the toxicity of Tetrabromophthalic Anhydride, to the
freshwater alga, Raphidocelis subcapitata, over a 72-hour exposure
The study was based on
procedures outlined in OECD Guidelines for Testing of Chemicals,
Guideline 201: Freshwater Alga and Cyanobacteria, Growth Inhibition
Test; and the Official Journal of the European Communities No. L383 A,
Method C.3.: Algal Inhibition Test.
The freshwater alga,
Raphidocelis subcapitata, was exposed to a series of five treatment
levels of Tetrabromophthalic Anhydride ranging from 2.5 to 41 mg/L,
based on mean measured concentrations. The toxicity of
Tetrabromophthalic Anhydride to Raphidocelis subcapitata was assessed
based on effects on cell density, growth rate, and yield relative to the
The 72-hour NOEC was
determined to be 41 mg/L based on a lack of statistically significant
reductions in cell density, growth rate, and yield in any of the
treatment groups. The 72-hour EC10 values for cell density, growth rate,
and yield were determined to be 32, >41, and 32 mg/L, respectively. The
72-hour EC50 values for cell density, growth rate, and yield were
determined to be >41 mg/L, for all three endpoints.
72-hour NOEC (cell density,
growth rate and yield): 41 mg/L.
72-hour EC50 (cell density,
growth rate, and yield) : >41 mg/L.
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