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EC number: 211-185-4
CAS number: 632-79-1
One rat at the 464 mg/kg dose was found dead
on the third experimental day. Necropsy findings
indicated the death was due to gavage error (e.g. intratracheal). No
other mortalities occurred during the 14-day observation. The
oral LD50 was determined to be > 10000 mg/kg bw. The
average body weight gain in each group was reported as within the normal
limits for rats of the age, sex and strain employed in the study. At
gross necropsy on termination, slight congestion of the kidney was
observed in rats at the lower dose levels, and moderate to marked
congestion of the kidneys were observed at the highest dose level.
The oral LD50 in mice was found to be > 10,000 mg/kg bw.
Four rabbits died between the 10th and
13thday of the study: 1 in the 1000 and 4640 mg/kg groups and
2 in the 2150 mg/kg group. Death was preceded by body
weight loss and diarrhea, and attributed to enteritis, a common syndrome
in laboratory rabbits. There were no other mortalities. The
LD50 was determined to be > 10000 mg/kg bw.
The oral LD50 in rats and mice was > 10000
mg/kg bw. The dermal LD50 in rabbits was > 10000 mg/kg bw. The inhalation
LC50 was > 10.92 mg/L.
The substance was not acutely toxic by the oral, dermal or inhalation routes.
Based on the available study data classification is not required in accordance with Regulation 1272/2008 (CLP)
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