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EC number: 304-780-6
CAS number: 94279-36-4
The long-term DNELs are based on a 28-day oral feeding study
performed in Sprague Dawley rats with 1,2,4-Benzenetricarboxylic acid,
decyl octyl ester (CAS 90218-76-1) as a Read Across substance. The NOAEL
in this study was found to be 300 mg/kg bw/day based on systemic effects
(reduced body weight, males; hair loss, females; increased leucocytes,
females and (reversible) effects on adrenals and liver) at the highest
dose of 1000 mg/kg bw/day. In another 28-day oral feeding study
performed withTris(2-ethylhexyl) benzene-1,2,4-tricarboxylate (CAS No.
3319-31-1), a surrogate substance, no adverse effects were observed up
to the highest dose of 1000 mg/kg bw/day. The long-term systemic DNELs
were derived based on the most sensitive NOAEL being 300 mg/kg bw/day.
As the DNELs were derived for the whole category, no adaption
regarding the molecular weight was done. However, the Read Across
substance tested in the respective study is the category member with the
lowest molecular weight und thus, the derived DNELs can be seen as the
worst case calculation with regard to the other category members.
The assessment factors were chosen according to ECHA Guidance
document R.8 (Characterisation of dose [concentration]-response for
human health, May 2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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