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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects up to the limit of water solubility (< 0.05 mg/L) for Daphnia magna based on read across (OECD 202)

Key value for chemical safety assessment

Additional information

The hazard assessment is based on the current data available. A study on long-term toxicity to aquatic invertebrates (OECD 211) is requested for 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS 94279-36-4) based on the ECHA decision on a compliance check (decision number CCH-D-2114517125-59-01/F). The long-term toxicity study on aquatic invertebrates could not be finalised until now due to the reasons explained in the document ‘CRO statement for Aquatic Toxicity Tests (OECD 210, 211 and 201) with EC 304-780-6’ (attached to the Endpoint Summary of IUCLID Section 6.1.4) showing in addition all dates from order to final report scheduled. The finalised study will be submitted later based on ECHA decision number CCH-D-2114517125-59-01/F. The aquatic toxicity will be re-evaluated in the update of this dossier as soon as the final aquatic studies will be available.

As no valid study is available for assessing the acute toxicity to aquatic invertebrates of 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS No. 94279-36-4), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was conducted.

The study with 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was performed under static conditions according to GLP and EU method C.2 using Daphnia magna as test organism. In this limit test the water-accommodated-fraction (WAF) of a 1 g/L stock solution was tested. The mean measured test concentration was 3.2 mg/L with 4.4 mg/L being the highest solubility attained at the beginning of the test (based on DOC content). Hence, under test conditions, the EC50 (48 h) is determined to be > 3.2 mg/L (measured, WAF).

Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, it can be concluded that tri-C9-11-alkyl esters (CAS No. 94279-36-4) is not expected to be acutely toxic to aquatic invertebrates.