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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20-30 Oct 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
column elution method
Remarks:
EU test method L142 A/57-66
Water solubility:
< 0.05 mg/L
Temp.:
20 °C
pH:
>= 5.7 - <= 7.7
Remarks on result:
other: pH value Milipore water: 6.7
Details on results:
See table below.

Quantitative determination of the analyte:

 

Flow rate, mL/h

Fraction No.

Water solubility, mg/L

pH

25.0

1(1-2)

< 0.05

7.6

2(3-4)

< 0.05

7.1

3(5-6)

< 0.05

7.7

4(7-8)

< 0.05

6.5

5(9-10)

< 0.05

6.6

6(11-12)

< 0.05

6.2

7(13-14)

< 0.05

6.1

8(15-16)

< 0.05

6.6

12.5

1(1-2)

< 0.05

6.4

2(3-4)

< 0.05

6.4

3(5-6)

< 0.05

6.5

4(7-8)

< 0.05

6.5

5(9-10)

< 0.05

6.5

6(11-12)

< 0.05

5.8

7(13-14)

< 0.05

5.7

8(15-16)

< 0.05

5.8

The calibration curve fits over the calibration range from 0.05 to 2.0 mg/L with r2 = 0.995.

In the course of the recovery experiment, a recovery rate of 83 % was determined.

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)

Description of key information

Insoluble. Water solubility < 0.05 mg/L at 20 °C (pH in the range from 5.7 to 7.7)

Key value for chemical safety assessment

Water solubility:
0.05 mg/L
at the temperature of:
20 °C

Additional information

There was an attempt performed, to determine the water solubility of the substance 1,2,4 -benzenetricarboxylic acid, tri-C9 -11 -alkyl esters (CAS 94279 -36 -4) according to the EC Guideline A.6. The water solubility measured was below the detection limit of 0.05 mg/L. Thus, the substance is insoluble in water.