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EC number: 304-780-6
CAS number: 94279-36-4
No toxic effects up to the limit of water solubility (< 0.05 mg/L) for Daphnia magna based on read across (OECD 202, part II, limit test)
As no valid study is available for assessing the acute toxicity to
aquatic invertebrates of 1,2,4-Benzenetricarboxylic acid,
tri-C9-11-alkyl esters (CAS No. 94279-36-4), in accordance to Regulation
(EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across
to the structurally related category member 1,2,4-Benzenetricarboxylic
acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was
conducted. The read across is justified due to a) the structural
similarity of the category members and b) similar physico-chemical
properties resulting in a similar environmental fate and ecotoxicity
profile. Further justification is given within the endpoint summary 6.1
and within the category justification section 13.
The study with 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl
triesters (CAS No. 90218-76-1) was performed under semi-static
conditions according to GLP and OECD guideline 202, part II using
Daphnia magna as test organism (Scholz, 1997). In this limit test the
water-accommodated-fraction (WAF) of a 1 g/L stock solution was tested.
The mean measured test concentration was 4.5 mg/L. Since no effects were
observed, on the basis of the mean measured test concentration the NOEC
(21 d) value for reproduction and survival of the parent animals is
determined to be ≥ 4.5 mg/L (measured, WAF), which corresponds to the
highest water solubility of the substance under test conditions.
Thus, based on the above mentioned results, and due to the structural
similarities and a consistent ecotoxicological/environmental fate
profile of the substances, as are explained with in the overall endpoint
summary in IUCLID chapter 6.1, it can be concluded that no chronic
toxicity of 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS
No CAS No. 94279-36-4) to aquatic invertebrates is expected.
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