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Diss Factsheets

Ecotoxicological information

Toxicity to terrestrial plants

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Administrative data

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Description of key information

LC50 (17-18d) > 100 mg/kg dry soil (nominal) for Triticum aestivum, Lepidum sativum and Brassica alba based on read across (OECD 208, limit test)

Key value for chemical safety assessment

Additional information

The assessment of the terrestrial toxicity should be based on the outcome of aquatic toxicity testing. Pursuant to ECHA decision on a compliance check CCH-D-2114517125-59-01/F new studies with the registered substance will be conducted in the future. The finalised studies will be reported in an updated dossier and the hazard assessment will be re-evaluated accordingly. Thus, the strategy of terrestrial toxicity will be evaluated later when all aquatic toxicity studies are available.


There are no adequate study data on terrestrial organisms of the registration substance available. The assessment was therefore based on studies conducted with the analogue substance 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006. Annex XI, 1.5. For each specific endpoint the source substance(s) structurally closest to the target substance is/are chosen for read-across, with due regard to the requirements of adequacy of the available data. Structural similarities and similarities in properties and/or activities of the source and target substance are the basis of read-across. A detailed justification is provided in the technical dossier (see IUCLID Section 13). Please consider that the originally proposed category approach addressing all Polyfunctional acid esters (PFAE) aromatic is currently under revision and will finally result in an analogue approach for the registration. Therefore, two documents, the category justification and explanatory notes for the analogue approach are provided in Section 13.


The study with 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters (CAS No. 90218-76-1) was performed under GLP and according to OECD guideline 208 using Triticum aestivum, Lepidum sativum and Brassica alba as test organisms. This limit test performed at a nominal concentration of 100 mg/kg dry soil was conducted in artificial soil. Effects of seedling emergence and seedling growth were determined during a test period of 17 days (B. alba) and 18 days (T. aestivum, L. sativum), respectively. No phytotoxic effects were observed in the control and the treatment for any tested species. Hence, the 17-18d-LC 50 for seedling emergence and growth are determined to be > 100 mg/kg dry soil.


Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, it can be concluded that no toxicity of 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS No. 94279-36-4) to terrestrial plants is expected.