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EC number: 304-780-6
CAS number: 94279-36-4
No toxic effects up to the limit of water solubility (< 0.05 mg/L) for Scenedesmus subspicatus based on read across (EU method C.3, limit test)
As no valid study is available for assessing the acute toxicity to algae
of 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS No.
94279-36-4), in accordance to Regulation (EC) No. 1907/2006 Annex XI,
1.5 Grouping of substances, a read-across to the structurally related
category member 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl
triesters (CAS No. 90218-76-1) was conducted. The read across is
justified due to a) the structural similarity of the category members
and b) similar physico-chemical properties resulting in a similar
environmental fate and ecotoxicity profile. Further justification is
given within the endpoint summary 6.1 and within the category
justification section 13.
The study with 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl
triesters (CAS No. 90218-76-1) was performed under static conditions
according to GLP and EU method C.3 using Scenedesmus subspicatus as test
organism (Scholz, 1994). The algae were exposed to six concentrations
ranging from 0.24 to 3.5 mg/L, which were prepared on the basis of a
water-accommodated-fraction (WAF) of a 1 g/L stock solution. Based on
the lack of effects on algal growth rate the EC50 (72 h) is determined
to be > 3.5 mg/L and the NOEC (72 h) is determined to be ≥ 3.5 mg/L on
the basis of the DOC content, which corresponds to the highest water
solubility of the substance under test conditions.
Thus, based on the above mentioned results, and due to the structural
similarities and a consistent ecotoxicological/environmental fate
profile of the substances, as are explained with in the overall endpoint
summary in IUCLID chapter 6.1, it can be concluded that no toxicity of
1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters (CAS No CAS No.
94279-36-4) to aquatic algae is expected.
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