Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-955-3
CAS number: 7782-42-5
Two qualities of Graphite were
considered for the present registration dossier: Synthetic Graphite (SG)
and Expanded Graphite (EG). Both are high purity graphite qualities with
SG having the higher purity (>99%) and no amounts of quartz or any other
crystalline impurities. EG however may contain certain (but low) amounts
of quartz (typical quantity: 0.9%) and muscovite (typical quantity:
With respect to sensitizing properties none of the impurities contained
in either of these qualities is of concern with respect to
sensitization. However, since EG was considered as the more adverse test
item compared to SG in all other studies conducted, it was chosen as
test item for this study as well, having in mind that the study results
are also valid for SG.
Migrated from Short description of key information:
- OECD 429 study
- Method according to Ehling et al. (see IUCLID 5 file) was used for assessment instead of radioactive labelling (acc. section 5 of OECD 429)
- Result: not sensitising
See section "Justification for classification or non-classification".
Based on the results of the present
study, there is no indication of any sensitizing potential of Expanded
Graphite (and consequently for SG). According to the provisions laid
down in Regulation (EC) No 1272/2008 Graphite is not a skin sensitizer.
Graphite failed to induce a positive
response in the LLNA for skin sensitisation and is therefore regarded to
be not a respiratory sensitiser. According to Guidance on Information
Requirements and Chemical Safety Assessment, Part 7a: and Kimber et al.
(cited in guidance): “The interpretation is therefore that a chemical
which fails to induce a positive response in the LLNA […] most probably
lacks the potential for respiratory allergy”. Additionally, none of the
data available showed any evidence for respiratory sensitization. Consequently,
according to provisions as laid down in Regulation (EC) No 1272/2008, Graphite
is not a respiratory sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again