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EC number: 231-955-3
CAS number: 7782-42-5
A bioaccumulation study is technically not feasible according to REACH
Annex XI, point 2.
OECD test guideline 305 on bioaccumulation in fish is applicable to
chemical substances for which it is possible to generate stable
solutions in water. Graphite, however, is completely insoluble in water
(see IUCLID section 4.8), which is established textbook knowledge.
Therefore, stable solutions of the substance in water are impossible to
maintain. In view of its insolubility, there is even no bioaccumulation
potential of graphite under realistic natural conditions. Neither would
a bioaccumulation study employing dietary exposure be feasible or useful
since graphite is an inert material that, based on its layered, planar
structure forming large macromolecules, can safely be expected to be
devoid of any potential to cross biological membranes. In conclusion,
due to the physicochemical and structural properties of graphite,
performing a bioaccumulation study in fish is technically not feasible,
fulfilling the criteria of REACH Annex XI, point 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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