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EC number: 231-955-3
CAS number: 7782-42-5
Two qualities of Graphite were
considered for the present registration dossier: Synthetic Graphite (SG)
and Expanded Graphite (EG). Both are high purity graphite qualities with
SG having the higher purity (>99%) and no amounts of quartz or any other
crystalline impurities. EG however may contain certain (but low) amounts
of quartz (typical quantity: 0.9%) and muscovite (typical quantity:
With respect to genotoxic properties Quartz may be the most problematic
impurity of EG (although the Quartz content is rather low), making EG
the worst case sample for assessing genotoxicity. Due to the fact that
SG does not contain Quartz, results
obtained for EG arevalid
for SG as well.
Short description of key information:
OECD 471 (bacterial reverse mutation)
- Four Salmonella strains and one E. Coli strain were used
- Plate incorporation method was applied
- Graphite did not induce neither with nor without S9 an increased number of revertants
OECD 473 (in vitro mammalian chromosome aberration test)
- Chinese Hamster Lung Fibroblasts (V79) cells were used
- Soy lecithin (in PBS) was used as an emulsifier for Graphite
- Graphite did not induce neither with nor without S9 the number of aberrant cells
OECD 476 (in vitro mammalian gene mutation)
- Mouse Lymphoma L5178Y/TK+/- cells were used
- Graphite die not induce neither with nor without S9 an increased numbers of TFT-resistant mutants
Endpoint Conclusion: No adverse effect observed (negative)
Results of all three OECD compliant
studies assessing genotoxicity had clearly negative outcome, hence there
is no evidence for any genotoxic potential of Graphite. According to
provisions laid down in Regulation (EC) No 1272/2008 Graphite is not
regarded as genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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