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EC number: 231-955-3
CAS number: 7782-42-5
- No study on toxicokinetics of Graphite was found
- Graphite belongs to the group of poorly soluble dusts with low toxicity, comparable to titanium dioxide
- In the available literature as well as in ECHA Guidance information on prolonged lung clearance after chronic exposure to poorly soluble dusts can be found
There was no study available dealing with
the toxicokinetics of Graphite powder. However, based on common
knowledge and all experimental data available in this dossier it is
reasonable to regard Graphite as a poorly soluble substance of low
toxicity, comparable to other representatives from the group of poorly
soluble dusts with low toxicity, such as Titanium dioxide (TiO2
is often used as a benchmark substance for this group of substances).
In an experiment preceding the repeated dose
studies, two Graphite qualities were assessed for differences in their
effects compared to DQ12 Quartz. Here BAL was used to quantify severity
of effects found. Additionally, gross pathology was performed. As a
result, no animals in any of the groups died due to the treatment. Also,
there was no sign of systemic toxicity - indicating that no adsorption
occurred. Recovery of the primary effects was not complete after 14
days, hence the recommendation to prolong the recovery period to 28 days
for the repeated dose studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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