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EC number: 231-955-3
CAS number: 7782-42-5
- One in vitro study (OECD 431) and one in vivo study (OECD 404) were conducted
- No signs of skin reaction were observed in the in vivo test
- Results of the in vitro assay were negative as well
- One in vitro study (acc. to recent (yet not validated) MatTek Corp. Neat-protocol) and one in vivo study (OECD 405) were conducted
- In the in vivo study only slight changes to the eyes were found, which were fully reversible
- Results of the in vitro assay were in the best possible category as well
Two qualities of Graphite were
considered for the present registration dossier: Synthetic Graphite (SG)
and Expanded Graphite (EG). Both are high purity graphite qualities with
SG having the higher purity (>99%) and no amounts of quartz or any other
crystalline impurities. EG however may contain certain (but low) amounts
of quartz (typical quantity: 0.9%) and muscovite (typical quantity:
possibly making it the slightly more adverse test item for studies
assessing skin irritation/corrosion or eye irritation. Due to the
absence of crystalline impurities and other impurities of concern in SG, results
obtained for EG are valid
for SG as well.
Following provisions laid down in REACH and for animal welfare reasons
prior to investigating both parameters in vivo, in vitro assays were
conducted. Results obtained from both in vitro assays justified
subsequent testing in animals.
the results obtained from all available studies on skin or eye
irritation, none of the criteria for classification as irritant to skin
or eye according to Regulation (EC) No 1272/2008 were met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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