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EC number: 231-955-3
CAS number: 7782-42-5
TABLE: Assessment of the formation
of erythema and oedema within the first 72hrs after the termination of
the exposure including the mean values calculated from the results of
Weight in kg
Observation assessment of the formation of erythema after the termination of exposure [hrs]
Observation assessment of the formation of oedema after the termination of exposure [hrs]
Only the scores for the 4hr exposure
from the readings after 24hrs. 48hrs and 72hrs are included in the
calculation of the individual mean values
al = anterior left
ml = middle left
pr = posterior right
The skin irritant effect of EXPANDED
GRAPHITE POWDER was investigated according to the method recommended in
the OECD Guideline 404 and the council regulation (EC) No. 440/2008 part
B.4. Based on the critical analysis of all known data performed by the
sponsor or monitor in his own responsibility the in vivo testing of the
test item was considered to be justified. During an initial test using
one female albino rabbit a sequential application (exposure time 3 min,
1 hr and 4 hrs) of EXPANDED GRAPHITE POWDER was carried out on one site
of the left and right back area each. The skin was examined for signs of
irritation straight after as well as 1 hr, 24 hrs, 48 hrs and 72 hrs
after the termination of exposure. Since the animal did not show any
signs of skin irritation within the observation period of 72 hours it
was decided to carry out a confirmatory test with two additional animals
in order to allow a categorization of the test item based on the
classification criteria. Two female albino rabbits were exposed to the
test item on one skin site of the back during the confirmatory test.
After 4-hour exposure time the test item was removed and the skin was
examined 1 hr, 24 hrs, 48 hrs and 72 hrs after the termination of
exposure. These animals did not show any skin reactions, either. Under
the experimental conditions described in this report the mean scores
after the 4-hour exposure were:
No. Erythema Oedema
4240 0.00 0.00
4302 0.00 0.00
4331 0.00 0.00
on the results of the study described in this report, EXPANDED GRAPHITE
POWDER has to be classified neither as irritant nor as corrosive
according to the provisions laid down in regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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