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EC number: 201-148-0
CAS number: 78-83-1
F0 and F1 parental survival were unaffected by test article exposure in
all exposure groups. No test article-related effects were observed on F0
and F1 reproductive performance (estrous cycles, mating and fertility
indices, the mean number of days between pairing and coitus and the mean
length of gestation), body weights, food consumption and food efficiency
in the 500, 1000 and 2500 ppm group males or females. Spermatogenic
endpoints (mean testicular and epididymal sperm numbers, sperm
production rate, motility, progressive motility and the percentage of
morphologically normal sperm) in the F0 and F1 test article-exposed
groups were unaffected by test article exposure. There were no test
article-related macroscopic findings or changes in mean organ weights in
the F0 or F1 males and females in the 500, 1000 and 2500 ppm groups.
Microscopic evaluation of the F0 and F1 males and females revealed no
test article-related histopathologic lesions, including for animals that
failed to breed or produce a litter. No test article-related effects on
primordial follicle counts and corpora lutea counts were observed in the
F1 2500 ppm group females. F1 and F2 pup survival and the general
physical condition of the pups were unaffected by exposure to the test
article. No test article-related effects on mean pup body weights were
observed in the 500, 1000 or 2500 ppm group F1 or F2 pups. No test
article-related macroscopic findings were observed in F1 or F2 pups that
were found dead or euthanized at the scheduled necropsy. There were no
test article-related changes in mean organ weights for the F1 or F2 pups.
The mean day of acquisition of balanopreputial separation or vaginal
patency and mean body weights on the day of acquisition in the F1 test
article-exposed pups were not affected by the test article.
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