2-methylpropan-1-ol

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference Type:

secondary source

Title:

"Ethnic contact urticaria to alcohol

Author:

Wilkin, J.K. and Fortner G.

Year:

1985

Bibliographic source:

Contact Dermatitis : Environmental and Occupational Dermatitis, Vol . 112, pp. 118-120; cited in OECD SIDS "Isobutanol", Final September 2004

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: Asian subjects who previously had reported severe facial flushing in response to oral ethanol ingestion

Principles of method if other than guideline:

Patch test

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpropan-1-ol

EC Number:

201-148-0

EC Name:

2-methylpropan-1-ol

Cas Number:

78-83-1

Molecular formula:

C4H10O

IUPAC Name:

2-methylpropan-1-ol

Method

Type of population:

general

Subjects:

- Number of subjects exposed: 3
- Demographic information: asian

Clinical history:

- History of allergy or casuistics for study subject or populations: severe facial flushing in response to oral ethanol ingestion

Controls:

Ethanol was used as a positive control agent

Route of administration:

dermal

Details on study design:

The skin was rated for the presence or absence of erythema immediately post-exposure.

Results and discussion

Results of examinations:

Dermal isobutanol exposure did not cause erythema in any of the test subjects. Ethanol was positive for erythema in these same test subjects.