Registration Dossier
Registration Dossier
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EC number: 201-148-0 | CAS number: 78-83-1
Specific investigations: other studies
Administrative data
- Endpoint:
- hepatotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Siegers C.P. et al.
- Year:
- 1 974
- Bibliographic source:
- Pharmacology, 12, 296-302, (1974); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung Nr.96, Ausgabe 01/97, BG Chemie,|Heidelberg, pp. 3-40, (1997)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Siegers C.P. et al.
- Year:
- 1 974
- Bibliographic source:
- Pharmacology, 12, 296-302, (1974); cited in WHO: Environmental Health Criteria 65, WHO, Geneva,pp. 93 ff., (1987)
Materials and methods
- Principles of method if other than guideline:
- Hepatotoxicity and effects on liver enzymes were studied after single oral application in guinea pigs.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-methylpropan-1-ol
- EC Number:
- 201-148-0
- EC Name:
- 2-methylpropan-1-ol
- Cas Number:
- 78-83-1
- Molecular formula:
- C4H10O
- IUPAC Name:
- 2-methylpropan-1-ol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- single
Doses / concentrationsopen allclose all
- Dose / conc.:
- 33.5 mg/kg bw (total dose)
- Dose / conc.:
- 335 mg/kg bw (total dose)
Results and discussion
- Details on results:
- No hepatotoxic effects were found 16 hrs after single oral application of 33.5 or 335 mg/kg isobutanol to Pirbright-White guinea pigs. No difference in the enzyme activities of serum SGOT, SGPT, and GLDH and in the triglyceride concentration were detected compared to a olive oil control group.
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