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EC number: 201-148-0
CAS number: 78-83-1
The negative control (solvent) values were all in or very close to the
expected range predetermined as historical controls of the laboratory.
The positive control group (cyclophosphamide) showed the expected
significant increase in the number of polychromatic erythrocytes with
2-Methylpropanol-1 has been assessed in this limit test in mice (5 males
or 5 females in one group; 500 and 1500 mg/kg bw, oral application) for
its potential to induce micronuclei. In a preceding range finding test
with 7 male mice, the dose of 1500 mg/kg bdw was strongly toxic and
mortality occurred in 3 animals. When females were treated with this
dose in the main study, one animal died in the 48 hour group. All other
4 females showed strong toxic reactions. Males have only been tested up
to 500 mg/kg bw. Also this dose caused strong toxic reactions but no
mortality. 48 Hours after administration of both doses of the test
material, no significant increase in the micronucleus frequency, as
compared to the negative control group, has been detected in males or
females. 24 Hours after start of the treatment with 1500 mg/kg bdw, no
increase in the micronucleus frequency was seen in the female group. In
the 4th group (males, 500 mg/kg bw; 24 hours), micronucleus frequency
was weakly (2 ‰ cells with micronuclei, negative control: 0.8 ‰) and
statistically significantly (p = 0.02) increased. As there was no dose
dependency and as this value was within the range of historical controls
(0.4 - 2.8 ‰), the test substance is not mutagenic under the selected
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