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EC number: 201-148-0
CAS number: 78-83-1
The blood concentrations of isobutanol, isobutyraldehyde, and isobutyric
acid were approximately 4, 4, and 17 µmol/L at the end of the
consumption period, clearly demonstrating that isobutyric acid was the
major metabolite of isobutanol metabolism. While the addition of ethanol
to the test beverage definitely altered the rate of isobutanol
metabolism (via a competition for metabolic enzymes), the presence of
ethanol did not affect how isobutanol was metabolized. Blood levels of
isobutanol decreased over the next two hours while the isobutyraldehyde
levels slowly increased in the blood. Isobutyric acid levels also
decreased after the end of the consumption period. Urinary
concentrations of isobutanol peaked at the one-hour postexposure time
point. Urinary levels of isobutyraldehyde peaked at the eight hour
post-exposure time point. Urinary levels of isobutyric acid peaked at
the end of the two-hour exposure period. Urinary levels of
propionaldehyde roughly followed those for isobutyraldehyde with peak
levels of approximately 8 µmol/L. Urinary levels of propionic acid rose
after the exposure period ended with plateau levels between 2 and 8
hours of approximately 60 µmol/L. Urinary levels of succinic acid
roughly followed the propionic acid urinary elimination curve with peak
levels of approximately 30 µmol/L. A diagram was provided in the paper
describing the further metabolism of isobutyric acid, ending with
propionic acid. The formation of succinic acid from propionic acid is
proposed based on the known intermediate metabolism of propionic acid
via the citric acid cycle.
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