Registration Dossier
Registration Dossier
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EC number: 201-148-0 | CAS number: 78-83-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Seven Day Skin Irritation study in Rabbits
- Author:
- Eastman Kodak co.
- Year:
- 1 986
- Bibliographic source:
- TSCATS: OTS 0510692; cited in OECD SIDS "Isobutanol", Final September 2004
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Rabbits were exposed to isobutanol for 7 d to determine the skin irritation potential after repeated dermal exposition.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylpropan-1-ol
- EC Number:
- 201-148-0
- EC Name:
- 2-methylpropan-1-ol
- Cas Number:
- 78-83-1
- Molecular formula:
- C4H10O
- IUPAC Name:
- 2-methylpropan-1-ol
Constituent 1
- Specific details on test material used for the study:
- Isobutanol
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Duration of treatment / exposure:
- 24 h per application
- Frequency of treatment:
- 4-6 x 24 hr
Doses / concentrations
- Dose / conc.:
- 0.3 other: mL undiluted test compound
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- Post-exposure period: 72 hr
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- other: local toxicity
- Basis for effect level:
- other: highly irritant after repeated exposure under occlusive conditions; no systemic toxicity reported
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Four to 6 times repeated 24-hr occlusive exposure to 0.3 ml isobutanol caused severe edema and erythema with eschar formation, which persisted throughout the 72-hr post-observation period. Isobutanol was therefore judged to be "highly irritant”.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
