Registration Dossier
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EC number: 204-445-3 | CAS number: 121-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The LD50 value for acute oral toxicity was > 300 < 2000 mg/kg b.w. in rats, the LD50 for acute dermal toxicity was > 2000 mg/kg b.w. in rats.
Key value for chemical safety assessment
Additional information
Oral exposure route:
In an acute oral toxicity study (BASF SE, 2010) performed according to the Acute Toxic Class method, doses of 2000 and 300 mg/kg bw of the test-item 4-Nitrotoluene-2-sulphonic acid (preparation in doubly distilled water) were administered to three test groups of three fasted Wistar rats each (2000 mg/kg bw in 3 females, 300 mg/kg bw in 6 females) by gavage in a sequential manner. All animals of the 2000 mg/kg test group were found dead within 2 days after the administration. No mortality occurred in the six females administered 300 mg/kg bw.
Clinical observation in the 2000 mg/kg bw test group revealed impaired and poor general state, dyspnoea, staggering, salivation, non feces, hemorrhagic urine, piloerection, ataxia and exsiccosis at hour 0 until study day 1 after administration. No clinical signs were observed in the first 300 mg/kg administration group. Clinical observation in the second 300 mg/kg test group revealed impaired general state, piloerection and dyspnoea in one animal from hour 1 until hour 2 after administration.
Dermal exposure route:
In an acute dermal toxicity study (Limit Test), young adult Wistar rats (5 males and 5 females) were dermally exposed to a single dose of 2000 mg/kg bw of 4-Nitrotoluene- 2-suphonic acid (as suspension in doubly distilled water) to the clipped skin and covered by semi occlusive dressing for 24 hours. No mortality occurred. (BASF SE, 2010)
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Harmful if swallowed, R 22
GHS classification (EU GHS, CLP 1272/2008)
- Harmful if swallowed, Category 4
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