Registration Dossier
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EC number: 204-445-3 | CAS number: 121-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no toxicokinetic studies available with the test substance. Therefore, the following assessment of the toxicokinetic behavior is based on the physicochemical properties of the test substance and the results from existing toxicological studies with the test substance.
Relevant physicochemical properties of the substance:
- substance is solid
- volatility: negligible; negligible vapour pressure at 20 and 50°C (<0.000001 hPa), melting point 133.5 °C
- molecular weight: 217.1992 g/mol
- logPow: -0.7 at 23°C and at pH = 1.3, -1.5 at 23°C and at pH = 2.3
- water solubility: 667 g/l at 23°C
Interpretation of data from acute toxicity studies and repeated dose toxicity (RDT) studies:
There are data on acute oral toxicity in rats (LD50 > 300 < 2000 mg/kg bw; BASF SE, 2010) and acute dermal toxicity in rats (LD50 > 2000 mg/kg bw; BASF SE, 2010). There are also data on oral RDT available, with a NOAEL (rat) = 150 mg/kg bw (GINC). After single or repeated oral application signs of systemic toxicity were observed indicating absorption of the test substance by this exposure route. After single dermal application no mortalities, clinical effects, specific target organ toxicity or any other changes were observed. This result is suggestive of a limited dermal absorption of the test substance.Supporting to the results from toxicological studies with oral administration, the properties of the test substance meet the physiological factors for GIT absorption (MW < 500 g/mol and moderate log POWbetween -1 and 4). According to the Danish (Q)SAR Database (EPI Suite, DERMWIN v2.09) and supporting to the lack of systemic effects in the acute toxicity study with dermal application, the dermal absorption of the test substance is estimated to be very low with an estimated Kp value of 2.78E-05 cm/hr. In contrast, the sensitising effect observed in a Local Lymph Node Assay with dermal application in mice (BASF SE, 2010) proved a certain dermal penetration of the test substance or metabolites thereof.
Based on the measured log Pow (-1.5 to -0.7) and the measured BCF (<4.1) of 4-nitrotoluene-2-sulphonic acid bioaccumulation is not expected.
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