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EC number: 254-052-6
CAS number: 38640-62-9
One key study concerning repeated dose toxicity was identified (Kawai, 1973; rat, oral, 6 months). In this study a NOAEL of 170 mg/kg/day was determined.
Repeated dose toxicity: oral
Four study reports were identified.
But only one oral study is assessed to be valid. In Kawai 1973,
bis(isopropyl)naphthalene (DIPN) was orally administered in diet for 6
months. Observations and evaluations correspond to test guideline
requirements. Kawai reports a NOAEL of 170 mg/kg bw/day for DIPN.
The oral 24 months study of Kawai
(1977) is a combined carcinogenicity/chronic toxicity study. But there
were only a few animals set up as satellites for treatment/observation
periods shorter than 24 months. Thus the endpoint chronic toxicity
(treatment period shorter than 24 months) is not adequately covered.
Observations at 24 months are largely influenced by age involution. Furthermore,
mortality was substantially increased at later time points (starting
from month 18) due to high incidence of pneumonia in all animals. The
derived NOAEL of 12 mg/kg bw/day is considered to be confounded by
secondary factors and, hence, not suitable to express the inherent
chronic toxicity potential of the test substance.
Repeated dose toxicity: dermal
No valid information is available. The
study record of Kureha 1979 only stands for a short abstract/summary
authored by Kureha Chemicals Industry Co. which does not provide sufficient
details for assessment.
Repeated dose toxicity: inhalation
No information could be located. With
respect to the low vapour pressure of diisopropylnaphthalene, inhalation
is considered to be a potential exposure route of minor practical
relevance. Moreover, given the low toxicity found after acute inhalation
as well as after repeated oral exposure it is concluded that adverse
effects following prolonged inhalation exposure will be low grade, too.
Repeated dose toxicity: via oral route - systemic effects
(target organ) digestive: liver
The NOAEL determined for repeated dose
toxicity of diisopropylnaphthalene exceeds guidance values for Danger of
serious damage to health by prolonged exposure according to Directive
67/548/EEC and for specific target organ toxicity - repeated exposure
according to regulation (EC) No. 1271/2008. Classification is not
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