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EC number: 254-052-6
CAS number: 38640-62-9
Elimination of 2,6-DIPN from various
tissues after administration of 0.1% DIPN in diet for 14 days (dosing
and sampling group 2)
Immediately after the end of
administration (day 0), levels in blood, liver, and kidney were 0.25 ±
0.04, 2.46 ± 0.66, and 1.77 ± 0.30 (µg/mL or µg/g) respectively (n = 3
to 4). At day 7, no 2,6-DIPN could be detected any more in these tissues.
At day 0, levels in skin and adipose
tissue were 23.41 ± 5.28 and 198.48 ± 4.69 µg/g respectively. After 28
days, still 10 % of the original concentration was left in skin. In
adipose tissue, DIPN levels of 23.97 ± 8.30 and 4.09 ± 0.05 µg/g were
detected after 7 and after 14 days. For the elimination of 2,6-DIPN from
adiose tissue, a biphasic course was determined with a half-life of 55 h
for the first phase (until ca. 21 days) and a half-life of 270 h for the
second phase (from 21 to 35 days).
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