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EC number: 254-052-6
CAS number: 38640-62-9
Waiving argument: Long-term toxicity testing in fish appears to be scientifically unnecessary, as data for a more sensitive species of a different trophic level is available.
For regulatory purposes as well as for
environmental risk assessment, only the lowest toxicity value in species
from three trophic levels is considered (see Guidance on information
requirements and chemical safety assessment, chapter R.7b: Endpoint
specific guidance, section 7.8.5, p. 41 - Threshold approach for
toxicity testing in fish).
Short-term toxicity tests with
diisopropylnaphthalene, available for species of three trophic levels
(invertebrates, aquatic plants and fish), suggest that Daphnia is the
most sensitive species (EC0 values being lower by a factor of 2 to 3
compared to the LC0 values in fish (EC/LC50 was not reached within the
water solubility of diisopropylnaphthalene).
Long-term toxicity tests are available
for daphnia (fresh water) and acartia tonsa (sea water). Based on the
sensitivity observed in short term tests, it is estimated that in
long-term tests daphnia will also be the most sensitive species. Thus
classification and derivation of PNECs will be based on long-term NOEC
obtained in invertebrate tests.
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