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EC number: 254-052-6
CAS number: 38640-62-9
Range finding study
Dose selection was based on the
range-finding study using 2 pregnant rats dosed at 100, 350, 750 and
1000 mg/(kg bw*d). 100 and 350 mg/(kg bw*d) were well tolerated, while
750 mg/(kg bw*d) was within the incipient maternal and fetotoxic range.
No developmental toxicity was observed
at the highest dose tested with incipient maternal toxicity.
Fertility rate: 95.5 % (control and
100 % (100- and
No significant differences from the
control were noted in all reproductive parameters.
Controls: 11.9 %
100-mg group: 5.8 %
250-mg group: 10.1 %
625-mg group: 9.4 %
* including one dead
No particular developmental adverse
effects on the fetuses of any treatment group were observed, comprising
physiological (body weight and body length) as well as morphological
parameters (malformations and variations).
Autopsy findings: none
There were no fetal deaths but one in
the 250-mg group.
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