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EC number: 254-052-6
CAS number: 38640-62-9
The dermal treatment induced slight
erythema down to a 20-% dilution. A 15-% dilution exhibited no primary
The test group as well as the control
group showed erythema after 24 and 48 h, with scores ranging
predominantly from 0.5 (slight, irregular erythema) to 1 (slight,
continuous erythema) and 2 (moderate erythema).
There was no significant difference
between test and control group.
Two valid studies are available to
assess the skin sensitizing potential of bis(isopropyl)naphthalene
(DIPN). In both studies, DIPN was demonstrated to be not sensitizing.
In a limited Buehler sensitization
test according to OECD TG 406, no erythema could be observed after
challenge exposure in the control and in the test group. Test results
indicate that the test substance DIPN is not sensitizing.
In a valid guinea pig maximization
test similar to OECD TG 406, slight erythemas were induced after
challenge exposure in control as well as in test group animals. There
was no significant difference between control and test group. Thus, the
test substance DIPN is assessed to be not sensitizing.
In two animal studies with guinea
pigs, diisopropylnaphthalene did not show a skin sensitising potential.
According to criteria set in either directive 67/548/EEC or Regulation
(EC) No 1272/2008, diisopropylnaphthalene is not sensitising.
Classification is not required.
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