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EC number: 254-052-6
CAS number: 38640-62-9
No lung damage/necrosis was observed
up to 3000 mg/kg (highest dose tested) at 24 h post treatment with and
without a GSH depletor, diethyl maleate (DEM), although the GSH level
was significantly reduced by the treatment. No or only mild changes in
GSH were evident up to ca. 600 mg/kg. No influence on lipid peroxidation
On contrast, naphthalene and
methylnaphthalene exhibited massive pathological disorders above approx.
200 and 400 mg/kg, respectively.
Note: Administration of naphthalene
and 2-methylnaphthalene caused a considerable depletion of pulmonary GSH
within 6 h, while 2-isopropyl and 2,6-diisopropyl naphthalene at doses
up to 3000 mg/kg bw caused only a slight GSH loss. But also despite
pretreatment with DEM associated with a decrease in pulmonary GSH, no
lung damage was produced by either test substance.
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