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EC number: 206-354-4
CAS number: 330-54-1
two-generation study in rats was conducted according EPA 83 -4, thus in
compliance with OECD 416 (Cook, 1990). Four groups of Wistar rats (30
males and 30 females per group) recieved Diuron at 0, 10, 250 or 1750
ppm in the diet for 73 days prior to mating, then during the mating
period and finally during pregnancy and weaning. The first (F1)
generation received Diuron during growth into adulthood, mating,
pregnancy, and until weaning of the second generation.
There were no
changes compared to control in body weight, food consumption, body
weight gains and food efficiencies at dosage groups up to 250 ppm in P1-
and F1-animals during pre-mating, mating and post-mating phases. Final
body weights, weight gains and overall food consumption of P1/F1 males
and females in the 1750 ppm groups were significantly lower than their
compound-related clinical signs or mortality were detected in the P1/F1
generations. There were no compound related effects apparent in the
mating index, fertility index, or gestation length in either the P1 or
F1 parental generations. There were no compound-related effects on
litter size or survival in either the F1 or F2 generations pups. Pups
weights (males and females) were decreased in both generations in the
1750 ppm dose group. Maternal weights were also decreased at this
dietary level of Diuron. Relative testis in P1/F1 males in the 1750 ppm
groups were increased, but this effect was due to the reduced body
weights and was judged not be a compound related effect. The increased
incidence of large spleen in the female F1 1750 ppm group correlated
microscopically with congestion. It was concluded by the authors that
the enlarged spleens were due to incomplete exsanguination at necropsy,
however, enlarged spleen is a commonly noted sign following
Diuron-treatment. Under the conditions of this study, the NOAEL is 250
ppm (equals 14.8 to 22.1 mg/kg bw/day) for both adults and their
Studies were available to access the developmental/teratogenicity of Diuron. A NOAEL for maternal was 10 mg/kg bw/day in rabbits and 16 mg/kg bw/day in rats, while the NOAEL for offspring was 80 mg/kg bw/day in rats. In rabbits, up to and including the highest dose tested, no effects were observed.
toxicity potential of Diuron was test in a reliable prenatal
developmental toxicity study equivalent or similar to OECD 414 inwhite
rabbits (Dearlove, 1986b).After
artificial insemination (=day 0 of presumed gestation) with spermatozoa
from bucks of the same source and strain, the 25 females per group
received oral doses of 0 (vehicle), 2, 10, and 50 mg Diuron /kg bw/d on
days 7 through 19 of presumed gestation.Overall,
a statistically significant decreasing average daily food consumption
and body weight gain was observed for the top dose on days 13 to 20,
resulting in significant weight loss to day 20, so that the NOAEL of
maternal toxic effects is set 10 mg/kg bw/d. In contrast, Diuron did not
adversely affect the development of the offspring at the top dose.
Therefore the NOAEL of embryotoxic / teratogenic effects is assessed to
50 mg/kg bw/d. (Dearlove1986b).
toxicity potential of Diuron was also tested in a prenatal developmental
toxicity study equivalent or similar to OECD 414 in Crl: COBS (SD) BR
stain rats. Female rats received oral doses of 0, 16, 80, and 400 mg/kg
bw Diuron once daily on days 6 through 15 presumed gestation. As the
administration of 80 mg/kg/d and
higher caused significantly reduced feed consumption and loss of body
weight during the period of treatment the NOAEL for maternal toxic
effects is determined to be 16 mg/kg bw/d. For foetuses average body
weights were significantly decreased for the high dosage group litters
and skeletal alterations and delayed ossifications were observed. That`s
why the NOAEL of embryotoxic/ teratogenic effects is set to 80 mg/kg
bw/d. (Dearlove, 1986a).
The available data on toxicity
to reproduction is conclusive but not sufficient for classification
according to directives DSD (67/548/EEC) or CLP (1272/2008/EC).
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