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EC number: 206-354-4
CAS number: 330-54-1
- After single intraperitoneal
administration of 700 mg/kg Diuron the
following symptoms were observed for up to 48 hours:
Apathy, roughened fur, staggering gait,
sternal recumbency, spasm, twitching, difficulties in breathing, rapid
breathing and eyelids closed.
Table 1: Summary
of results of micronucleus test with Diuron (after acute intraperitoneal
treatment with 700 mg/kg bw)
Number of evaluated PE1)
Number of NE2)per 1000 PE1)
Micronucleated cells per 1000
CPA 20 mg/kg
* p< 0.05 in non-parametric Wilcoxon ranking
** p< 0.01 in non-parametric Wilcoxon
1) polychromatic erythrocytes
2) normochromatic erythrocytes
micronucleus test in mice was conducted according to OECD 474 and EEC
guidelines. After single i.p.
treatment with 700 mg/kg bw Diuron no mortalities were observed, but all
animals showed signs of toxicity. No
increase in micronucleated PCEs over solvent control was noted at any
sampling time point, so no indications of a clastogenic effect of Diuron
were found. (Herbold,
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