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EC number: 206-354-4
CAS number: 330-54-1
dermal administration of Diuron at dose levels up to 250 mg/kg bw/d, no
mortalities or toxic effects occurred.No
behavioural changes were noted. Examination of the skin according to
Draize or skin fold thickness determination did not show any alterations.
and blood chemistry exhibited no differences between the groups.
Neither relative nor
absolute organ weights were affected. Histopathology revealed congestion
of the spleen in only one male rabbit. No other toxicologically relevant
histopathological findings were noted.
repeated dose dermal toxicity study is partially according to OECD
Guideline 410. Rabbits
were exposed to 50 and 250 mg/kg bw/d of Diuron for five days per week
over three weeks. The repeated dermal exposure to Diuron revealed no
toxicologically relevant effects on rabbits. That`s why the the NOAEL is
set to 250 mg/kg bw, the highest dose tested. (Mihail and Schilde, 1984)
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