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EC number: 206-354-4
CAS number: 330-54-1
Short description of key information on bioaccumulation potential result: In rats Diuron is rapidly absorbed, metabolised and excreted after single and repeated oral and inhalation exposure.
Refer to basic toxicokinetics.
Discussion on bioaccumulation potential result:
Diuron was used to investigate its biokinetic behaviour in the Wistar
rat (Weber and Abbink, 1988). The substance was administered to male and
female rats in a single oral dose of 5 or 200 mg/kg bw, or a single
intravenous dose of 5 mg/kg body weight. Animals of both sexes were also
given fifteen daily oral doses of 5 or 200 mg/kg body weight. A bile
cannula was inserted prior to treatment of the male rats given the
single 5 mg/kg bw oral dose. The radioactivity in the excreta, blood and
bile was measured at various times. The radioactivity in the tissues and
the carcass was determined at the time of sacrifice. The recovery rate
ranged from 92 to 107% of the radioactivity administered.
radioactivity was almost completely absorbed following oral
administration of Diuron. A total of more than 95% of the recovered
radioactivity was thus found in the urine (57.4%), bile (37.7%) and in
the residual body (0.5%) in animals with bile fistulas. The levels of
radioactivity in the blood reached a peak 1.7 to 6.8 hours after
treatment. Thus, the absorption is relatively quick and almost complete.
radioactivity was rapidly eliminated from the animal body. More than 97%
of the balanced radioactivity was eliminated from the body via urine and
faeces within 72 hours after treatment in all the animal groups.
Elimination was mainly via the urine (68 – 87% of total dose), 50% of
the total being eliminated within eight hours after treatment and 90%
within 12 hours in nearly all cases. Male rats with bile cannulae
eliminated about 38% of the recovered amount in the bile within 48
hours, about 57% in the urine, and only about 4% in the faeces
indicating entero-hepatic circulation.
Only a very
small amount of radioactivity (0.01%) could be detected in the expired
air within three days after oral administration of a single 200 mg/kg bw
levels of radioactive residues were found in the animal excluding the
gastrointestinal tract three days after treatment (0.5 - 0.8% of the
balanced radioactivity following a single dose, and 1.1 - 2.5% after
multiple doses). The dose-normalised concentrations in the animal
excluding the gastrointestinal tract after a single dose were P = 0.0054
- 0.0067. The relative concentrations rose by a factor of 3 - 5 after
multiple doses. This indicates that the tissues were not saturated by
the 15 multiple doses indicating accumulation to be unlikely. The
overall tissue concentration was very low due to the fast excretion of
distribution and elimination of Diuron were independent from dose levels
the metabolism of Diuron in the Wistar rat following inhalation was
investigated (Pauluhn and Eben, 1986). Animals were exposed to Diuron
concentrations of 4.1, 37.4 or 268.1 mg/m3over periods of
four and eight weeks. The urine of the individual animals was collected
over a period of 18 hours following the exposure and extracted. Aliquots
were acid-hydrolysed. The percentages of the metabolites were based on
the molecular weight of Diuron, and on the amount of Diuron inhaled over
a period of one day.
metabolite formed after inhalation of Diuron was
3,4-dichlorophenyl-urea, which was exclusively eliminated in the form of
the free compound (3.6 - 13.3%). Other metabolites, e. g.
3,4-dichlorobenzenamine and N-(3,4-dichlorophenyl)-N’-methyl-urea, were
excreted as conjugates only. The unchanged substance (0.1 - 0.2%) was
only detected in the urine of animals from the two highest dose groups.
A total of 6.1 - 18.6% of the daily inhaled quantity of Diuron was
excreted in the form of the compounds mentioned.
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