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EC number: 206-354-4
CAS number: 330-54-1
The most sensitive LD50 is 1017 mg/kg bodyweight for Diuron when administered after rats were fed regular laboratory chow diet 28 days prior to dosing. In addition, there are several reliable studies showing that the rather low toxicity of Diuron and that the toxicity, if observed, was attributed to the diet and vehicle used in the studies and not to the substance itself.All available acute inhalation studies on Diuron by the inhalation route showed no toxic effect at the tested concentrations. All available acute inhalation studies on Diuron by the dermal route showed no toxic effect at the tested concentrations.
Acute oral toxicity:
In a reliable acute
toxicity study comparable to guideline OECD 401 female rats were dosed
with 25, 50, 100, 2500, 5000 and 7100 mg/kg bw Diuron (Heimann and
Thyssen, 1983). At the lowest dose level, no clinical signs were noted.
Higher dose levels revealed behavioural, respiratory and motility
disorders. Some animals exhibited a narcosis-like state and lying on
side or stomach. Signs were noted between 27 min (high dose levels) and
2 hours at lower doses following administration. Mortalities occurred at
2500 mg/kg and above within 2 days. Therefore, the LD50 was calculated
to be 4150 mg/kg bw. Various other studies confirmed the low toxicity of
Diuron with LD50 values > 2000 mg/kg bodyweight (Mihail, 1981,
Heimann,1984 and Sanders, 2007).
However, when Diuron was
dissolved in cotton seed oil and administered to rats receiving a
protein-deficient diet the LD50 was 437 mg/kg bw in male Wistar rats
(Boyd & Krupa, 1970). The
LD50 for rats of the low protein diet was lower as compared to rats fed
non-protein deicient diet. The study indicates that Wistar rats are much
more susceptible to acute oral toxicity of Diruon when fed
protein-deficent diet. Therefore, the LD50 value of 1017 mg/kg bw
will be used to trigger C&L as this was derived from standard conditions
(this LD50 was derived after feeding the test animals regular laboratory
chow). Based on this study, Diuron is considered to be harmful upon
& Krupa, 1970)
Moreover, for Diuron
administered in peanut oil, oral LD50 values of 1258 and 1182 mg/kg bw
were reported in male and female Sherman rats (Gaines and Lindner
studies indicate that rats are more susceptible to acute oral toxicity
of Diuron when fed protein-deficient diet and that Diuron exhibited a
much higher oral toxicity in cotton seed oil than watery preparations.
Thus showing the toxicity could be attributed to the diet and vehicles
used in the studies.
Nontheless, based on the
most critical LD50 of 1017 mg/kg bodyweight, Diuron needs to be
classified according to the criteria of Directives 67/548/EEC (DSD) and
In a reliable acute
inhalation toxicity study performed according to OECD 403, five male and
female Sprague-Dawley rats were nose only exposed to 5.05 mg/L Diuron,
the max. achievable atmosphere concentration (Griffith, 2007). One
female rat died on day 1 post-exposure.Clinical signs noted during the
study included increased respiratory rate, hunched posture,
pilo-erection and wet fur. At necropsy, no macroscopic abnormalities
were detected amonst surviving animals except for one instance of
abnormally dark lungs. The animal that died showed abnormally dark lungs
and an accentuated lobular pattern in the liver. Based on the results of
this , the LC50 in the rat is considered to be > 5.05 mg/L Diuron.
Acute Dermal Toxicity:
In a reliable study in
accordance to OECD 402 rats were dermally exposed to 2500 and 5000 mg/kg
bw Diuron. At the low dose level no clinical signs were noted and at the
high dose level animals only showed reduced motility and apathy for 2 to
4 days. Therefore, the LD50 is determined to be > 5000 mg/kg bw (Heimann
and Thyssen, 1983).
Based on the available data on acute oral
toxicity Diuron needs to be classified:
CLP: acute toxicity 4
The data on acute toxicity for the
inhalation and dermal route are conclusive, but not sufficient for
classification according to
directives DSD (67/548/EEC) or CLP (1272/2008/EC).
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