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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: Published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Effect of prolonged individual caging on toxicity parameters in rats.
Author:
Wiberg, G.S., Grice, H.C
Year:
1965
Bibliographic source:
Fd. Cosmet. Toxicol. 3:597-603.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Details on exposure:
KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.
Doses:
660 mg
No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
660 mg/kg bw
Based on:
test mat.
Remarks on result:
other: KCl was administrated as a single dose by the intraperitoneal route to groups of 10 rats.

Applicant's summary and conclusion

Conclusions:
The LD50 value of 660 mg/kg was determined in this study by intravenous route of administration
Executive summary:

The LD50 value of 660 mg/kg was determined in this study by intravenous route of administration