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Long-term toxicity to aquatic invertebrates

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Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
other: Published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
Potassium was added a geometric series of concentrations for obtaining approximation of toxicity. After determination of test concentration, 8 groups of animals were tested at the mean nominal concentrations 54,8 and 102.8 mg potassium /l added to Lake Superior water with 1.2 mg chloride /l. Test concentrations were renewed each week. Test temperature was 18 ±1 oC and photoperiod 18 hours. Reproduction was assessed each week by counting juveniles produced. Three to seven tests were performed and the results of all tests were pooled and statistically analysed.
GLP compliance:
not specified
Analytical monitoring:
yes
Vehicle:
yes
Details on test solutions:
Potassium was added a geometric series of concentrations for obtaining approximation of toxicity. After determination of test concentration, 8 groups of animals were tested at the mean nominal concentrations 54,8 and 102.8 mg potassium /l added to Lake Superior water with 1.2 mg chloride /l. Test concentrations were renewed each week. Test temperature was 18 ±1 oC and photoperiod 18 hours. Reproduction was assessed each week by counting juveniles produced. Three to seven tests were performed and the results of all tests were pooled and statistically analysed.
Test organisms (species):
Daphnia magna
Details on test organisms:
SPECIES #
(NAME): 5 Daphnia magna
(Water Flea)
AGE: 12 h
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
semi-static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
21 d
Hardness:
45.3 mg/L CaCO3
Test temperature:
18 °C
pH:
7.74
Dissolved oxygen:
9 mg/L
Reference substance (positive control):
not specified
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
68 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
as potassium
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
97 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
as potassium
Basis for effect:
immobilisation
Remarks on result:
other: 87 mg/l-108 mg/l
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
87 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
as potassium
Basis for effect:
immobilisation
Details on results:
A 21d NOEC of 68 mg/L has been determined for the effects of the test substance (as potassium) on reproduction of the Daphnia magna.
A 21d NOEC of 87 mg/L has been determined for the effects of the test substance (as potassium) on immobilisation of the Daphnia magna.
Validity criteria fulfilled:
yes
Conclusions:
A 21d NOEC of 68 mg/L has been determined for the effects of the test substance (as potassium) on reproduction of the Daphnia magna.
A 21d NOEC of 87 mg/L has been determined for the effects of the test substance (as potassium) on immobilisation of the Daphnia magna.
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.0/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not required
Vehicle:
not specified
Test organisms (species):
other: Daphnid species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
30 d
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
-Name of test material (as cited in study report:Potassium oxide
CAS Number: 12136-45-7
SMILES : KOK
CHEM : Potash (potassium oxide)
MOL FOR: O1 K2
MOL WT : 94.20
Values used to Generate ECOSAR Profile

Log Kow: -1.380 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 1E+006 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Reference substance (positive control):
no
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
273.134 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: cited as a ChV value
Details on results:
Daphnid, 30-day,NOEC for freshwater species cited as ChV (chronic value) = 273.134 mg/L (ppm)

Overview of QSARs estimations on long-term aquatic toxicity of  of Dipotassium oxide/Potassium oxide to Daphnid     

Method

 

Results

Remarks

Reference

QSAR

estimate

 

 Daphnid, 30-day, ChV (chronic value) = 273.134 mg/L (ppm)

 

Daphnid , 48-hr LC50 =  6675.5 mg/L (ppm)

 

Reliable with restrictions,

QSAR estimated data

ECOSAR Program (v1.00)

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 273.134mg/l. 

 

Daphnid, 30-day, ChV (chronic value) = 273.134 mg/L (ppm)

Daphnid , 48-hr LC50 = 6675.5 mg/L (ppm)

 

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Daphnid, 30-day,NOEC cited as ChV (chronic value) = 273.134 mg/L
Executive summary:

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 273.134 mg/l .

Description of key information

A 21d  NOEC of 68 mg/L  has been determined for the effects of the test substance (as potassium) on reproduction of the Daphnia magna.
A 21d NOEC of 87 mg/L has been determined for the effects of the test substance (as potassium) on immobilisation of the Daphnia magna.
ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 273.134 mg/l
The available data for saltwater invertebrates are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to NOEC following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa
21-day NOEC(Salt water) =8.7 mg/L (ppm)
 

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
87 mg/L
EC10, LC10 or NOEC for marine water invertebrates:
8.7 mg/L

Additional information

A 21d NOEC of 68 mg/L has been determined for the effects of the test substance (as potassium) on reproduction of the Daphnia magna.

A 21d NOEC of 87 mg/L has been determined for the effects of the test substance (as potassium) on immobilisation of the Daphnia magna.

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 273.134 mg/l

 

The available data for saltwater invertebrates are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to NOEC following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa

 

 

21-day NOEC(Salt water) =8.7 mg/L (ppm)