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EC number: 235-227-6
CAS number: 12136-45-7
Potassium oxide has not bioaccumulation potential.
Potassium is essential constituent and one of the most abundant ions in
all animal species. In adult humans, the total body potassium is approx.
3.5 mol (135 g). 98 % of this is located intracellular (150 mmol/l), the
extracellular potassium concentration is approx. 4 mmol/l.
Oxygen is the most abundant chemical element by mass in the Earth's
biosphere, air, sea and land. Oxygen is the third most abundant chemical
element in the universe, after hydrogen and helium
Both K+ and O- ions are normal constituents of the body fluids. K+ plays
an essential role in the human physiology but starts to be toxic at
levels exceeding 200 – 250 mg/l. Its concentration in the blood is
regulated principally by renal excretion/reabsorption and controlled by
an efficient feedback auto-regulation system. An excessive pH of the
blood is prevented by the bicarbonate buffer system, respiration and
renal compensation mechanisms.
Bioconcentration/bioaccumulation was estimated using QSAR estimation
software (EPISUITE v4.1 BCFBAF v3.01), in accordance with REACH Annex
XI. The estimated log BCF is 0.5 (BCF = 3.16 L/kg wet-wt) using
the regression-based method.
The estimated log BAF is -0.05 (BAF = 0.894 L/kg wet-wt) using the
Arnot-Gobas upper trophic method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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