Dipotassium oxide

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: (Q)SAR method with established scientific validity

Qualifier:

no guideline followed

Principles of method if other than guideline:

BCFBAF v3.01 in EPI Suite (v4.1)

GLP compliance:

no

Remarks:

not applicable

Radiolabelling:

no

Vehicle:

no

Test organisms (species):

other: QSAR model

Route of exposure:

other: QSAR model

Test type:

other: QSAR model

Water / sediment media type:

not specified

Remarks:

freshwater

Hardness:

QSAR model

Test temperature:

QSAR model

pH:

QSAR model

Dissolved oxygen:

QSAR model

TOC:

QSAR model

Salinity:

QSAR model

Nominal and measured concentrations:

QSAR model

Reference substance (positive control):

not required

Type:

BCF

Value:

3.162 L/kg

Basis:

whole body w.w.

Remarks on result:

other: regression based method

Type:

BAF

Value:

0.894 L/kg

Basis:

whole body w.w.

Remarks on result:

other: Arnot-Gobas (upper trophic)

Details on results:

--------------------------------- BCFBAF v3.01 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.00627 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.05 (BAF = 0.894 L/kg wet-wt)

Log Kow (experimental): -1.38
Log Kow used by BCF estimates: -1.38

Equation Used to Make BCF estimate:
Log BCF = 0.50

Correction(s): Value
Correction Factors Not Used for Log Kow < 1

Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)

Reported statistics:

Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.00627 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.05 (BAF = 0.894 L/kg wet-wt)

Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)

Biotransformation Half-Life (days) : 0.00627 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): -0.05 (BAF = 0.894 L/kg wet-wt)

Validity criteria fulfilled:

yes

Conclusions:

QSAR estimation using the BCFBAF v3.01 of the EPISUITE 4.1 indicate that the BCF of Potassium oxide is 3.162 L/kgwwt. This is well below the threshold for Bioaccumulation (B) for the PBT determination.

Executive summary:

Bioconcentration/bioaccumulation was estimated using QSAR estimation software (EPISUITE v4.1 BCFBAF v3.01), in accordance with REACH Annex XI. The estimated log BCF is 0.5 (BCF = 3.16 L/kg wet-wt) using the regression-based method.

The estimated log BAF is -0.05 (BAF = 0.894 L/kg wet-wt) using the Arnot-Gobas upper trophic method.

Description of key information

Bioconcentration/bioaccumulation was estimated using QSAR estimation software (EPISUITE v4.1 BCFBAF v3.01), in accordance with REACH Annex XI. The estimated log BCF is 0.5 (BCF = 3.16 L/kg wet-wt) using the regression-based method.
The estimated log BAF is -0.05 (BAF = 0.894 L/kg wet-wt) using the Arnot-Gobas upper trophic method.

Key value for chemical safety assessment

BCF (aquatic species):

3.16 L/kg ww

Additional information

Bioconcentration/bioaccumulation was estimated using QSAR estimation software (EPISUITE v4.1 BCFBAF v3.01), in accordance with REACH Annex XI. The estimated log BCF is 0.5 (BCF = 3.16 L/kg wet-wt) using the regression-based method.

The estimated log BAF is -0.05 (BAF = 0.894 L/kg wet-wt) using the Arnot-Gobas upper trophic method.